IJspeert et al published in the American Journal of
Gastroenterology findings from a randomized
trial in which computed tomography
colonography (CTC) and colonoscopy were compared for the detection of high-risk
sessile serrated polyps (SSP) in average-risk individuals.
Sessile serrated polyps (SSPs) are considered
to be the precursors of 15–30% of all colorectal cancers (CRCs).
Therefore, CRC screening modalities should be designed to detect high-risk
SSPs.
The authors invited 8,844 individuals to
join in the trial, of which 1,276 colonoscopy and 982 CTC invitees participated
in the study. In the colonoscopy arm, 4.3% of individuals were diagnosed with ≥1
high-risk SSPs, compared with 0.8% in the CTC arm. In total, 3.1% of individuals
in the colonoscopy arm were diagnosed with high-risk SSPs as most advanced
lesion, compared with 0.4% in the CTC arm. The current CTC strategy showed a marked
lower detection for especially flat high-risk SSPs (17 vs. 0), high-risk SSP
located in the proximal colon (32 vs. 1), and SSPs with dysplasia (30 vs. 1).
As sessile serrated polyps are considered
precursors of colorectal cancers screening modalities should detect them with
high rate of accuracy. Findings from
this trial suggest that the detection rate of high-risk SSPs was significantly higher
with colonoscopy than computed tomographic colonography.
No comments:
Post a Comment