According to a study published in Radiology, by Lee SM et al from Seoul,
South Korea they report on a retrospective analysis of percutaneous biopsies of lung
lesions performed on 1108 patients in the period between January 2009 and December 2011. The gender distribution in this study was 633 males and 475 females with a mean age of 62.4 years.
The diagnostic performance, complication rate, influencing factors and patient radiation exposure, of the 1116 lesions (mean size 2.7 cm) that were biopsied with an 18-gauge co-axial needle were evaluated. Of the nodules biopsied 766 were malignant (66.4%), 323 were benign (28%) and 59 were indeterminate (5.1%). The sensitivity, specificity and accuracy for the diagnosis of malignancy were 95.7%, 100% and 97% respectively. There were five technical failures and 33 biopsies were false negative. Lesions in the lower lobes, multiple passages and emphysema were risk factors. Pneumothorax occurred in in 196 (17%) and hemoptysis in 80 (7%) patients. Mean estimated radiation dose during the procedure was 7.3 mSv +/- 4.1.
The authors conclude that Cone-beam CT-guided biopsy is an accurate and safe means to diagnose lung lesions.
The diagnostic performance, complication rate, influencing factors and patient radiation exposure, of the 1116 lesions (mean size 2.7 cm) that were biopsied with an 18-gauge co-axial needle were evaluated. Of the nodules biopsied 766 were malignant (66.4%), 323 were benign (28%) and 59 were indeterminate (5.1%). The sensitivity, specificity and accuracy for the diagnosis of malignancy were 95.7%, 100% and 97% respectively. There were five technical failures and 33 biopsies were false negative. Lesions in the lower lobes, multiple passages and emphysema were risk factors. Pneumothorax occurred in in 196 (17%) and hemoptysis in 80 (7%) patients. Mean estimated radiation dose during the procedure was 7.3 mSv +/- 4.1.
The authors conclude that Cone-beam CT-guided biopsy is an accurate and safe means to diagnose lung lesions.
Lee SM, Park CM, Lee KH, Young E: Transthoracic
Needle Biopsy of Lung Nodules: Clinical Experience in 1108 Patients. Radiology, Vol 271(1), April 2014: 291-300
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