Combined MRS and DWI could Predict Stroke's Outcome

Parsons etal in their article that appeared in Neurology¹ report on the prognostic value of the biochemical changes seen with proton MR spectroscopy (MRS) in patients with ischemic stroke.

Nineteen patients had 36 1H MRS studies, 13 of the patients acutely (mean, 11.1 hours), 10 patients sub-acutely (mean, 3.9 days), and 13 patients at outcome (mean, 82 days). Single-voxel, long-echo, timepoint-resolved spectroscopy was used to obtain lactate, n-acetylaspartate (NAA), choline, and creatine levels from the infarct core. Diffusion-weighted imaging (DWI) was used to identify regions of ischemia for 1H MRS voxel localization.  Outcome measures were final infarct volume and clinical assessment scales (Canadian Neurological Scale, Barthel Index, and Rankin Scale).

Acute lactate/choline ratio correlated more strongly with clinical outcome scores and final infarct size than acute DWI lesion volume or acute NAA/choline ratio. Combination of acute lactate/choline ratio and DWI lesion volume improved prediction of all outcome scores. The predictive effect of acute lactate/choline ratio was independent of acute DWI lesion volume (p < 0.001). In subacute and chronic infarction, both lactate/choline and NAA/choline ratios continued to correlate with outcome (p < 0.05). At the chronic stage, persistent lactate/choline ratio elevation strongly correlated with outcome measures (r = 0.71 to 0.87).

The authors concluded that lactate/choline ratio measured in the acute infarct core by 1H MRS improves the prediction of stroke outcome and provides prognostic information complementary to DWI.

1. Parsons M, Barber P, Yang G, Darby et al: Combined (1)H MR spectroscopy and diffusion-weighted MRI improves the prediction of stroke outcome. Neurology. 2000 Aug 22;55 (4):498-505